Nexium, a proton pump inhibitor, is commonly prescribed for gastroesophageal reflux disease (GERD), peptic ulcers, and Zollinger-Ellison syndrome. While the brand-name version of Nexium is available in the U. S., the brand-name product is also available in other countries and is available in a wide variety of formulations.
The global Nexium (Esomeprazole) market was valued at USD 1.2 billion in 2023 and is projected to reach USD 1.6 billion by 2031, growing at a CAGR of 7.6% during the forecast period of 2024-2031[1][4].
Several factors are driving the growth of the Nexium (Esomeprazole) market:
Increasing Prevalence of Gastroesophageal Reflux disease: The growing incidence of gastroesophageal reflux disease (GERD) and peptic ulcers is a significant driver. Nexium, a proton pump inhibitor, is commonly prescribed for GERD and peptic ulcers[1]. However, other formulations, such as Pepcid, reduce the prevalence of these conditions[4]. Another factor is the growing awareness of GERD and peptic ulcers[2][5]. Other significant drivers include the growing prevalence of Zollinger-Ellison syndrome, which is a rare genetic disorder that causes blistering of the stomach and esophagus that can impair the ability to stomach acid production[2][3][4]. Additionally, the rising incidence of GERD and peptic ulcers due to improvements in lifestyle and dietary habits is a significant driver[4]. In addition to the increasing prevalence of GERD and peptic ulcers, the growing awareness of GERD and Zollinger-Ellison syndrome is another significant factor[4].
Growing Acceptance of Rheumatoid Arthritis: The acceptance of rheumatoid arthritis as a treatment option for patients with reflux symptoms has expanded the market reach of Nexium among patients with established symptoms. Patients with established rheumatoid arthritis also benefit from the proton pump inhibitor's use[2].
Expansion of Non-Aspirin Nexium Formulations in Europe: Improvements in diet and exercise levels are driving the adoption of Nexium in Europe, especially among patients with established conditions such as Zollinger-Ellison syndrome or gastrointestinal disorders[1].
The cost of Nexium (Esomeprazole) in the U. S. was approximately USD 126 for a supply of 30 capsules, making it the most expensive medicine in the market. A supply of 30 capsules could be priced at USD 400 for a supply of 60 capsules[2].
The market is competitive, with several major players including Novartis AG, the largest manufacturer of proton pump inhibitors (PPIs), Apotex, Teva Pharmaceutical Industries Ltd., Johnson & Johnson, Dr. Reddy's Laboratories, Ltd., and others. These companies are focusing on expanding their product portfolios and product portfolios expansion efforts[1][4].
The market is segmented across various regions, with North America, Europe, South America, the Middle East, Africa, and the Asian markets being the primary regions studied. North America is expected to dominate the market, followed by Europe, Asia Pacific Freeamination, and Latin America. Asia Pacific Freeamination, where Nexium is sold, is also expected to dominate the market[4].
Alternate Name:Pharmapure RX Esomep-EZS
Description:Nexium treats gastroesophageal reflux disease (GERD), esophagitis, and stomach ulcers. The generic version of Nexium is esomeprazole magnesium. For a supply of 30 oral tablets of Nexium Delayed-Release Capsules 40 mg is approximately $287. Take advantage of our LowerMyRx discount to receive a typical Nexium discount of up to 80% off of the retail price at participating pharmacies near you.
Dosage Form:Capsule Delayed Release
Administration Route:By mouth
Drug Class:Gastric Acid Secretion Inhibitor, Gastrointestinal Agent
Generic Available:Yes
Strength:20 MG
Warnings:Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, lupus, vitamin B12 deficiency, or osteoporosis. This medicine may cause the following problems: Kidney problems, including acute tubulointerstitial nephritisIncreased risk of broken bones in the hip, wrist, or spine (more likely if used several times per day or longer than 1 year)Serious skin reactions, including Stevens-Johnson syndrome, toxic epidermal necrolysis, acute generalized exanthematous pustulosis, and drug reaction with eosinophilia and systemic symptoms (DRESS)LupusFundic gland polyps (abnormal growth in the upper part of your stomach) This medicine can cause diarrhea. Call your doctor if the diarrhea becomes severe, does not stop, or is bloody. Do not take any medicine to stop diarrhea until you have talked to your doctor. Diarrhea can occur 2 months or more after you stop taking this medicine. Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results. Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments. Keep all medicine out of the reach of children. Never share your medicine with anyone. Stomach pain, nausea, vomiting, weight loss, bloody or black stools
Food Warnings:Do not use esomeprazole if you are also using medicines that contain rilpivirine., Some medicines can affect how esomeprazole works. Tell your doctor if you are using any of the following: Atazanavir, cilostazol, diazepam, digoxin, erlotinib, ketoconazole, methotrexate, mycophenolate mofetil, nelfinavir, rifampin, saquinavir, St John's wort, tacrolimus, voriconazoleBlood thinner (including clopidogrel or warfarin)Diuretic (water pill)Iron supplements, This medicine can cause diarrhea. Diarrhea can occur 2 months or more after you stop taking this medicine., Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results., Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments., Keep all medicine out of the reach of children.
Food Not to BuyThis medicine is not for daily use, never share your medicine with anyone, use esomeprazole without consulting your doctor, or if you are pregnant, unless your doctor has it out. This medicine may cause the following problems: Kidney problems, including acute generalized exanthematous pustulosis, Drug reaction with eosinophilia and systemic symptoms (DRESS)LupusFundic gland polyps (abnormal growth in the upper part of your stomach, especially in the right part of your stomach) This medicine can cause diarrhea.
Nexium is used to treat frequent heartburn in people who have acid reflux disease (GERD). It is also used to prevent heartburn from occurring again if acid reflux occurs. Nexium works by decreasing the amount of acid that your stomach produces. This helps to reduce symptoms such as heartburn and acid reflux.
When used as directed by your doctor, this medicine may be taken with or without food. Do not increase or decrease the amount of food you are allowed without the doctor's approval.
Your doctor will determine the right amount of this medicine for you based on your medical history and the amount of food you are allowed to eat. Ask your doctor or pharmacist for more details.
Your doctor will do a blood test to check your levels of, which are important for preventing heartburn and heartburn from occurring again. These tests will show your acid levels in your blood, which will help to determine how much acid your body is able to absorb.
This test may also help you to measure the amount of time it takes to absorb acid. This medicine may take several weeks to show its full effects.
Lab tests that take between 30 minutes to an hour to show effects will vary from person to person. These tests show how long the medicine will take to work. Some people may experience the following symptoms:
These tests may also show that your body is working properly to absorb the medication and help to reduce symptoms.
You may be taking this medicine with or without food.
Some studies have found that taking Nexium during pregnancy can cause birth defects. Tell your doctor if you are pregnant or plan to become pregnant.
It may be best not to take Nexium during breastfeeding unless your doctor tells you to.
Your doctor may recommend hormone replacement therapy if you are unable to absorb the medication. Your doctor will check to see if the hormone replacement therapy is right for you.
Your doctor may change your dose or recommend that you have a blood test to check the level of your, which is important for preventing heartburn and heartburn from occurring again. This test will show how long the medicine takes to work.
This test may also help you to measure the amount of time it takes to work. Some people experience the following symptoms:
This test may also show that your body is working properly to absorb the medication and help to reduce symptoms.
A new study shows that over-the-counter proton-pump inhibitors are just as effective as brand-name versions in reducing the risk of heart attacks and strokes.
The study by researchers at Boston University School of Medicine, which included nearly 2,000 people, was published today in the journalClinical Gastroenterology. The study, published in theAnnals of Internal Medicine, was led by Dr. Andrew Goldstein, the lead author of the study, and led by Drs. Lisa L. Goldstein and Stephen B. Wahl. It is the first time that over-the-counter (OTC) drugs are being compared with their prescription counterparts in reducing heart attacks and strokes in patients with a history of heart disease, including recent heart attacks and strokes.
The study is the latest in a series of studies in which over-the-counter proton-pump inhibitors are shown to be more effective than the brand-name counterparts.
The researchers looked at data from over a million people who had heart disease, heart attacks, and strokes for at least two years between 2008 and 2012, and whether they were able to prevent or stop the disease.
The researchers found that the combination of over-the-counter proton-pump inhibitors reduced the risk of heart attacks and strokes by about 40% — and by about 25% — compared to the brand-name counterparts.
The researchers also found that people who were given the brand-name versions of Nexium, Prevacid, Prilosec, Protonix, and Teva had a significantly lower rate of heart attacks and strokes.
But they also found that those who were given over-the-counter PPIs had a significantly higher risk of developing heart attacks, a type of heart disorder, compared with those who were given the brand-name PPIs.
“The results of this study suggest that patients who were given PPIs may be at increased risk of developing heart attacks and strokes, but at a lower risk than those who were given the nonprescription PPIs,” Goldstein commented.
“In addition, these results highlight the importance of using the information provided by the study to help patients and their health care providers recognize potential benefits and risks.”
The authors of the study noted that they have received multiple grants from the U. S. National Heart, Lung and Blood Institute, which provides funding to support the study.
“This study provides a valuable opportunity to assess the effectiveness of nonprescription proton-pump inhibitors in reducing the risk of developing heart disease and heart attacks, particularly in people who are at increased risk of heart disease,” the study concluded.
The findings were published inThe Lanceton Monday.
Linda E. Rosenstock / ReutersAbout the author:Michael L. Goldstein, MD, and Stephen B. Wahl, MD, lead authors of the new study, co-chaired the International Society for Gastroenterology and Hepatology conference, which is sponsored by AstraZeneca.
The new study is published in the journal, and will be posted online on January 20.
Dr. Andrew Goldstein, an endocrinologist and gastroenterologist at Harvard Medical School and the co-chaired theBritish Medical Journal, presented the study at theBritish Medical Journal Internationalin February.The results of the study, published in, show that over-the-counter proton-pump inhibitors are just as effective as brand-name versions in reducing the risk of heart attacks and strokes.
“This is the first time that over-the-counter PPIs have been compared to brand-name PPIs in preventing or treating heart disease and stroke,” Dr. Goldstein said.
“The results of this study suggest that patients who were given PPIs may be at increased risk of developing heart attacks and strokes, but at a lower risk than those who were given the nonprescription PPIs,” Dr. Goldstein noted.
“This study provides a valuable opportunity to assess the effectiveness of nonprescription proton-pump inhibitors in reducing the risk of developing heart disease and heart attacks, particularly in people who are at increased risk of developing heart disease,” the study concluded.
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